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KMID : 0665220180310060828
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Korean Journal of Food and Nutrition
2018 Volume.31 No. 6 p.828 ~ p.835
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Protective Effect of 6 Food Mixed-Extract on the CCl4-Induced Hepatic Damage in Rats
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HwangBo Mi-Hyang
Yea Chun-Jung
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Abstract
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The objective of this study was to examine the biochemical parameters of hepatic function such as serum level of ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDH (lactate dehydrogenase), and content of TG (triglyceride) and cholesterol, and tissue immunological changes of the CCl4-treated rats with administration of the mixed sample extract (MSE). The liver weight in CCl4-administered experimental control group (EC) was slightly higher than that of normal control (NC) group. Hepatic damage parameters (ALT, AST, ALP, LDH & TG) in serum of the EC group were significantly higher than those in serum of the NC and silymarin-treated positive control (PC) group.
On the other hand, these hepatic damage parameters of MSE-treated experimental (E1 & E2) groups were significantly lower than those of EC group. The number of WBC, neutrophils, lymphocytes and platelets, and the contents of hemoglobin, and hematocrit in EC group were significantly higher than those of NC group. However, the number of WBC and lymphocytes in E1 and E2 groups were significantly lower than those of EC group. Also, the collagen developmental areas in the liver of NC and PC groups by hepatic immuno-histological findings were found slightly positive. Whereas, hepatic fibrous developmental tissue of EC group was strongly positive brown color band, those of E1 & E2 groups were decreased.
Therefore, it was concluded that the induction of hepatic fibrous tissue activation had a preventive effect of MSE against the CCl4-induced hepatic damage in rats. However, further study is needed in this filed.
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KEYWORD
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liver, hematological, tetrachlorid, biochemical, hepatic damage, immunological
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